Historically, the aging process and its consequences were thought to be intractable. In recent years, however, a wealth of empirical data has emerged showing that longevity can be extended in model organisms by manipulating individual genes. The advantages of model systems lie in reduced costs, ease of maintenance in a laboratory environment, and affordable but rigorous manipulation tools. In general, the simpler the organism we use as a model, the greater these advantages. Researchers have discovered that the lifespan of model organisms, such as yeasts, fruit flies (Drosophila melanogaster), and mice, can be significantly extended through genetic and environmental manipulation. At CD BioSciences, we have been dedicated to longevity research for years and offer longevity model customization services to unlock the secrets of extended lifespan.
Yeast models have long been crucial tools for understanding the fundamental mechanisms underlying longevity. Our team of experts at CD BioSciences helps clients customize long-lived yeast models, allowing them to explore novel pathways and interventions that can extend longevity. By carefully selecting and manipulating the genes involved in the Ras-PKA and TOR-Sch9 pathways, our scientists can customize long-lived yeast models. Furthermore, our clients can utilize these models to unveil the fundamental mechanisms of longevity and the pathogenesis of age-related diseases.
From dietary interventions and environmental manipulations to genetic modifications, we offer customized solutions to help clients generate long-lived Drosophila. Our scientists possess expertise in genetically engineering Drosophila with extended lifespans, enabling clients to investigate the complex interplay of genetic, environmental, and behavioral factors that influence longevity. By overexpressing key genes involved in stress response and disrupting the insulin/IGF-1 signaling pathway, we can boost the flies' defenses against age-related decline and extend their lifespan.
At CD BioSciences, we take great pride in our ability to provide customized long-lived genetic mouse models. Our team of skilled experts helps clients generate genetically engineered mouse lines with extended lifespan, allowing them to explore the complex interplay of genetic, environmental, and physiological factors that contribute to healthy aging. At present, we can help clients customize Ames, Snell, Little, Laron, p66shc mutant, and IGF-1R knockout mouse models. We mainly offer transgenic and genome editing approaches.
The Fukomys mole-rat has garnered significant attention in the longevity research community due to its remarkable longevity and resistance to age-related diseases. At CD BioSciences, we have established a dedicated platform for customizing Fukomys mole-rat models, enabling our clients to investigate the unique adaptations and molecular mechanisms underlying the extended lifespan of these fascinating rodents. Furthermore, our services provide a platform to study the underlying mechanisms behind this unique disease resilience, which informs the development of novel anti-aging interventions.
The naked mole-rat is another intriguing model organism in aging research, known for its exceptional longevity and apparent resistance to age-related pathologies. Our customized naked mole-rat models allow clients to delve into the genetic, epigenetic, and physiological mechanisms that underlie this extraordinary lifespan, potentially revealing novel targets for anti-aging interventions.
At CD BioSciences, we firmly believe that the key to unlocking the secrets of longevity lies in the ability to tailor research models to the unique requirements of each project. Drawing upon our extensive knowledge base, we help clients generate customized solutions that accelerate the pace of discovery in the field of longevity research. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
Copyright © 2024 CD BioSciences. All rights reserved.