Long-Lived Yeast Strain Customization Services

INQUIRY

In aging research, yeast has proven to be an invaluable tool for studying the fundamental mechanisms that govern aging and lifespan. The long-lived yeast strain is a genetically modified variant of Saccharomyces cerevisiae that exhibits an extended lifespan compared to wild-type strains. This extension in lifespan is achieved through various genetic manipulations that target specific pathways known to influence aging. Leveraging yeast as a model system, CD BioSciences is working to help clients customize long-lived yeast stains to change the way that researchers study longevity and age-related diseases.

Yeast

Customization Options for Long-Lived Yeast Models

Selection of long-lived yeast model types

We offer tailored solutions for both chronological life span (CLS) and replicative life span (RLS) extensions, allowing our clients to choose the approach that fits their research objectives. In yeast models, CLS refers to the survival of non-dividing, stationary-phase yeast cells, while RLS measures the number of daughter cells a mother cell can produce before senescence.

Options of lifespan extension methods

At CD BioSciences, we offer a range of customized strategies to generate long-lived yeast stains, catering to the diverse needs and preferences of our clients.

Pharmacological inhibition of the longevity regulating pathway. We employ pharmacological inhibition of the key longevity regulatory pathways to help clients achieve CLS or RLS extension. By carefully selecting and administering inhibitors, such as rapamycin and methionine sulfoximine (MSX), our team can induce a state of slow but not blocked growth, thereby promoting extended lifespan in yeast models.
Genetically modification. Our skilled scientists can utilize targeted genetic engineering techniques to introduce specific longevity-enhancing mutations or overexpress key longevity regulators. Our approach allows for sustained modulation of yeast lifespan, tailored to the unique requirements of each research project.

Selection for longevity regulatory pathways

Longevity regulatory pathways	Service details
Inhibition of Ras-PKA signaling	The Ras/PKA pathway plays a crucial role in regulating yeast cell growth, metabolism, and stress response. By carefully selecting and manipulating the genes involved in the Ras-PKA pathway, our scientists at CD BioSciences can customize yeast models with increased longevity.
Inhibition of TOR-Sch9 signaling	The TOR-Sch9 pathway is another critical regulator of yeast longevity, governing cellular growth, metabolism, and stress response. We help clients customize yeast models with extended lifespan by manipulating the genes and proteins involved in this signaling cascade. Our services involve the genetic or pharmacological inhibition of the TOR kinase or the overexpression of the Sch9 kinase inhibitor, Rim15.

Applications of Yeast Models with Extended Lifespan

The customized yeast models developed by CD BioSciences have a wide range of applications in longevity research. Our clients can utilize these models to elucidate the fundamental mechanisms of cellular aging and screen for potential longevity-promoting compounds. Furthermore, the yeast model with an extended lifespan can help clients unveil the pathogenesis of age-related diseases, such as neurodegenerative disorders, metabolic syndromes, and cancer.

At CD BioSciences, we are committed to empowering our clients with the yeast model with an extended lifespan to advance the frontiers of longevity research. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

Mirisola MG, Longo VD. Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells, 2022, 11 (10): 1714.
Powers RW, et al. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev, 2006, 20 (2): 174-84.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.