Lifespan is 15-25% heritable in humans and as much as 48-79% heritable in mice, indicating that both genetic and environmental factors influence the aging process and may be open to manipulation. One of the essential tools for studying the biological mechanisms underlying aging is animal models that show alterations in aging, especially those that show delayed aging. Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. It has been reported that several mutant mice with defects in the growth hormone/insulin-like growth factor 1 (GH/IGF-1) pathway are dwarfed and have an extended lifespan.
Fig. 1 Mouse models with shortened or extended lifespans generated by genetic manipulation of genes involved in genome maintenance. (Folgueras AR, et al., 2018)
CD BioSciences provides long-lived genetic mouse model customization services. We are dedicated to offering our clients the reliable tools to unlock the secrets of longevity and push the boundaries of scientific discovery.
We offer a comprehensive range of mouse strains, including but not limited to C57BL/6, BALB/c, and 129S, each with its own unique genetic and physiological characteristics. Our in-depth knowledge of mice allows us to guide our clients in selecting appropriate strains to address their specific research objectives.
We have amassed a wealth of knowledge on the genetic pathways and mechanisms underlying longevity. Our scientists carefully collaborate with clients to identify promising candidate genes for lifespan extension, such as those involved in cellular senescence and metabolic regulation pathways.
| Genetic pathways | Service details |
| Cellular senescence pathways | Our scientists have studied the genetic regulators of cellular senescence, such as the p16-Rb and p53-p21 pathways, and have developed strategies to modulate these pathways to promote extended lifespan in mouse models. |
| Metabolic regulation pathways | We have extensive expertise in identifying and targeting genes involved in metabolic regulation, including those associated with insulin/IGF-1 signaling, AMPK activation, and mitochondrial function. By optimizing the expression or activity of these key metabolic regulators, we can generate mouse models with enhanced metabolic efficiency and extended lifespan. |
Depending on the research goals and the specific targeted genes, CD BioSciences offers a variety of genetic modification methods to generate long-lived genetic mouse models. We mainly offer transgenic and genome editing approaches.
CD BioSciences has extensive experience in developing long-lived mouse models that exhibit a significantly extended lifespan compared to their wild-type counterparts. Our customized models are invaluable for studying the fundamental mechanisms of aging, as well as for evaluating the efficacy of longevity-enhancing interventions.
At CD BioSciences, we are driven by the pursuit of scientific excellence and a deep commitment to providing our clients with advanced services in the customization of genetic mouse models. If you are interested in our services, please feel free to contact us or make an online inquiry.
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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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