Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents despite their small body mass (~ 32 g). Their maximum lifespan is over 30 years. This is ten times longer than that of mice and five times longer than expected based on body mass. Phenotypic aging appears to be virtually absent for 80% of their lifespan, including sarcopenia, neurodegeneration, disease, and cancer. Based on sustained fecundity and an age-independent mortality rate, some authors even suggest that the naked mole-rat is the first known example of a non-aging mammal.
Fig. 1 Adult naked mole-rats kept in an animal room. (Oka K, et al., 2023)
As a leading provider of customized naked mole-rat models and aging research services, CD BioSciences empowers researchers to unlock the secrets of longevity and uncover novel therapeutic avenues for health aging.
Our team of experts can design and implement specialized dietary regimens for the naked mole-rat models, exploring the impact of caloric restriction, nutrient supplementation, or targeted dietary interventions on lifespan extension and age-related resilience. By precisely controlling the naked mole-rat nutritional intake, we empower clients to investigate the intricate relationship between diet, metabolism, and longevity.
We offer a suite of advanced phenotyping services, including lifespan analysis, age-related biomarker tracking, and comprehensive physiological assessments. Our team of scientists will work closely with clients to design and execute tailored longitudinal studies, providing clients with invaluable data to support their research goals.
To unravel the mechanisms underlying the naked mole-rat remarkable longevity, we offer a wide range of specialized physiological and biochemical assays. Our services include the measurement of body temperature, metabolic rate, fasting glucose, glucose tolerance test (GTT), insulin, thyroid hormones, body fat percentage, and more.
We offer comprehensive genomic analysis services, including but not limited to DNA damage assessment and DNA mutation identification. By delving into the naked mole-rats genetic architecture and its resistance to age-related genomic instability, our services help clients identify novel targets and develop innovative strategies to promote healthy aging.
Our team of experts specializes in the evaluation of protein homeostasis in naked mole-rat models, including the study of protein folding, aggregation, and clearance mechanisms. Our services help clients understand how the naked mole-rats effectively control protein quality to uncover potential therapeutic avenues for age-related proteinopathies and neurodegenerative diseases.
The remarkable resilience of the naked mole-rats tissues, even at advanced ages, is a testament to their impressive longevity. We offer comprehensive services to assess the structural and functional integrity of naked mole-rat tissues, including stem cell dynamics, cellular senescence, and regenerative capacity.
At CD BioSciences, our expertise and capabilities help clients uncover the fundamental mechanisms underlying the naked mole-rat remarkable lifespan and resilience. If you are interested in our services, please feel free to contact us or make an online inquiry.
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