Non-GLP Toxicology Services for Anti-Aging Drug Development

Understanding the safety of anti-aging drugs is vital for successful development and eventual market approval. Non-Good Laboratory Practice (non-GLP) toxicology studies help researchers evaluate the potential adverse reactions of new drugs. These studies facilitate the early identification of toxicological risks, which can save time and resources in later stages of development. Moreover, the non-GLP approach allows for more flexible study designs and faster turnaround times, making it an ideal choice for clients looking to advance their drug candidates without the constraints of extensive regulatory requirements.

CD BioSciences offers specialized non-GLP toxicology services for anti-aging drug development to support the preclinical evaluation of new therapeutics. We enable clients to manage the complexity of anti-aging research confidently.

Our Non-GLP Toxicology Services for Anti-Aging Drug Development

Dose Ranging and Maximum Tolerated Dose Studies

We help clients conduct dose ranging studies by administering anti-aging drugs at different doses. We selected multiple species, often including rodents and non-rodents, to evaluate how different organisms respond to the drug at varying levels. During studies, our experts observe and record adverse indicators such as changes in behavior, physiological responses, and any signs of toxicity. Using rigorous protocols, we also offer maximum tolerated dose (MTD) studies that involve increasing dosing followed by observation of adverse reactions.

Repeat Dose Toxicity Studies

By assessing hematological and biochemical markers and performing detailed histopathological examinations, we can help clients perform repeat dose toxicity studies over extended periods to evaluate the safety of administered drugs.

Acute Toxicology Services

We offer acute toxicity studies to evaluate the effects of anti-aging drugs within a short period of time. Specifically, we provide acute inhalation, oral, and dermal toxicity testing, skin sensitization testing, and acute eye irritation/corrosion testing. Our skilled experts provide essential data on the immediate effects of anti-aging drugs, including dose-response relationships and potentially lethal doses.

Subchronic and Chronic Toxicity Studies

We offer subchronic and chronic toxicity studies to help clients assess the long-term effects of anti-aging drugs. Our services are crucial for understanding long-term safety profiles and identifying cumulative toxic effects. We help clients design routes of administration, dosage, and exposure duration. We also help assess behavioral changes, body weight, food and water intake, and signs of toxicity. Our testing evaluates long-term effects on multiple organ systems, assessing renal function, liver enzymes, and neurological health. Our rigorous protocols ensure that our clients receive thorough and reliable data.

Genetic Toxicology Services

We offer genetic toxicology testing that is vital for identifying potential mutagenic effects of anti-aging drugs. At CD BioSciences, we employ a range of assays, including Ames tests, chromosomal aberration assays, micronucleus tests, and comet assays, to evaluate the genotoxic potential of new drug candidates. Our services are crucial for assessing whether anti-aging therapeutics pose risks of carcinogenesis or heritable genetic damage.

Carcinogenicity Studies

At CD BioSciences, we offer in vitro and in vivo assays to evaluate the carcinogenic potential of anti-aging drugs. For preliminary screening, we offer a range of established human cell lines representing different tissues and cancer types, allowing a rapid assessment of the potential carcinogenicity of the anti-aging drugs. We also use rodent models in carcinogenicity studies for anti-aging drugs. Our experts help clients monitor tumor growth in treatment and control groups.

Relevant Routes of Administration

The route of administration has a significant impact on the pharmacokinetics and pharmacodynamics of any drug. CD BioSciences offers a variety of drug administration routes to meet the needs of clients, including:

• Conventional routes of administration. Oral administration, intravenous administration, subcutaneous administration, intradermal administration, and intramuscular administration.
• Special routes of administration. Intranasal, retinal injection, rectal, intracerebral stereotaxic, intrathecal, intraventricular, etc.

Sample Collection for Toxicology Analysis

Proper sample collection is crucial for the integrity of toxicology studies. CD BioSciences can collect various types of samples for toxicology studies. Our meticulous sample collection protocols ensure that our clients receive comprehensive data to support their anti-aging drug development.

• Blood
• Urine
• Feces
• Cerebrospinal fluid

At CD BioSciences, our non-GLP toxicology services for anti-aging drug development provide a foundation for early evaluation. Our expertise in conducting these studies, combined with our comprehensive analytical capabilities, supports the advancement of safe and effective anti-aging therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.