Mitochondria play an essential role in energy generation, cell signaling, differentiation, death, and senescence in eukaryotic cells. During senescence, mitochondria undergo changes that affect their structure and function. Senescent mitochondria have dysfunctional membranes and impaired energy production, which can lead to oxidative stress and cell damage. CD BioSciences, a leading provider of comprehensive biological analysis services, offers comprehensive mitochondrial analysis services during senescence.
CD BioSciences employs a wide range of techniques to analyze mitochondrial morphology and ultrastructures with high resolution. Through advanced imaging technologies such as electron microscopy and confocal microscopy, we can visualize changes in mitochondrial structures, including alterations in shape, size, and cristae organization. Our comprehensive analysis of mitochondrial-associated membranes (MAMs) during aging includes morphology studies, lipid composition, protein profiling, and assessments to discern age-related changes in MAM integrity and functions.
In addition, our sophisticated image analysis algorithms allow for quantitative assessment of these changes, providing valuable insights into the dynamics of mitochondrial networks during aging. By characterizing these structural changes, we can gain a deeper understanding of the functional consequences and potential therapeutic targets for age-related diseases.
In addition to structural alterations, age-related changes in mitochondrial functions have significant implications for cellular health and aging. CD BioSciences offers a comprehensive suite of assays to evaluate mitochondrial function during senescence. These assays encompass a wide range of parameters, including mitochondrial respiration, oxidative phosphorylation, membrane potential, and mitochondrial permeability transition pore.
We leverage a range of technology and advanced data analysis tools to deliver mitochondrial calcium ion detection services, including mitochondrial calcium load testing, handling efficiency, flux assessment, and biomarker analyses. Additionally, we also provide a wide range of mitochondrial autophagy analysis services, such as mitochondrial autophagy flux measurements, aging-related mitochondrial autophagy marker assays, and aging-related mitochondrial autophagy pathway analysis services.
CD BioSciences offers advanced analytical methods, such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS), to measure and quantify mitochondrial metabolites, providing valuable insights into their role in aging.
We offer comprehensive services for the analysis of nicotinamide adenine dinucleotide (NAD+) levels and related pathways in aging biology. Our analysis aims to elucidate the influence of NAD+ on the immune system and aging-related diseases. We also analyze tricarboxylic acid (TCA) cycle intermediates in aging, allowing for the quantification of TCA cycle intermediates, such as citrate, isocitrate, α-ketoglutarate, succinate, fumarate, and malate, in biological samples.
Mitochondrial analysis during senescence is a critical area of research for understanding the aging process and developing interventions to promote healthy aging. CD BioSciences, with its extensive experience and customized solutions, is a trusted partner in providing comprehensive mitochondrial analysis services. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
Copyright © 2024 CD BioSciences. All rights reserved.