Mitochondria are dynamic organelles with intricate internal structures, including the inner and outer membranes, cristae, and matrix. As organisms age, several notable changes can occur in mitochondrial structures. These changes encompass alterations in mitochondrial size, shape, distribution, cristae organization, inner membrane integrity, and matrix density. Age-related changes can also affect the connections of mitochondria with other cellular components, such as the endoplasmic reticulum, through mitochondrial-associated membranes (MAMs). At CD BioScience, we are dedicated to understanding and analyzing these age-related changes in mitochondrial structure to assist in the study of aging and age-related diseases.
Our advanced microscopy techniques and image analysis tools allow for the detailed examination of mitochondrial morphology, including changes in size, aspect ratio, circularity, and distribution within aging cells. We analyze variations in mitochondrial size, including length, width, and volume. We also perform circularity measurements to assess the roundness or elongation of mitochondria.
We eventually provide our clients with comprehensive data analysis, including the assessment of mitochondrial morphological parameters and insightful interpretation of the findings to support their progression of aging research initiatives.
Through transmission electron microscopy (TEM) and 3D electron tomography techniques, we can provide in-depth analyses of ultrastructural changes in aging mitochondria. Our service assesses mitochondrial ultrastructure that changes with aging, including the arrangement of cristae, inner and outer membranes, and matrix density.
Upon completion of the analysis, our clients receive a comprehensive report that includes high-resolution images, quantitative data on morphological parameters, and an in-depth analysis of age-related ultrastructural changes.
Our comprehensive analysis of MAMs during aging includes morphology studies, lipid composition, protein profiling, and assessments to discern age-related changes in MAM integrity and functions. Our services are characterized by a well-structured workflow that encompasses sample preparation, experimental execution, data acquisition, and in-depth data analysis.
We observe the morphology and spatial organization of MAM in the samples. We also perform mass spectrometry or protein profiling of the proteome of MAM. In addition, we extract lipids from MAM samples and perform liposome analysis using mass spectrometry (MS) techniques.
Analysis of age-related structural changes in mitochondria is imperative for unraveling the intricacies of at the cellular level and identifying potential therapeutic targets for age-related diseases. At CD BioScience, we take pride in our cutting-edge technologies and multidisciplinary approach to studying age-related changes in mitochondrial structures. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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