Analysis of the Role of Mitochondrial Metabolites in Aging

Aging is a biological process that involves the progressive decline of cellular functions, leading to the deterioration of tissues and organs. Mitochondria, known as the 'powerhouses' of the cell, play a crucial role in aging biology by generating adenosine triphosphate (ATP), the primary energy currency of the cell. However, they also produce various metabolites that have been implicated in the aging process.

Fig. 1 Mitochondrial metabolic pathways. (Moindjie H, et al., 2021)

At CD BioSciences, we understand the importance of studying mitochondrial metabolites in aging biology. Our company specializes in providing comprehensive services and solutions for researchers and professionals in the field of aging research.

Analysis of Nicotinamide Adenine Dinucleotide in Aging

At CD BioSciences, we offer comprehensive services for the analysis of nicotinamide adenine dinucleotide (NAD⁺) levels and related pathways in aging biology. Our advanced technologies, such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS), enable accurate measurements of NAD⁺ and its metabolites. By studying NAD⁺ dynamics and its role in cellular processes, we aim to contribute to the advancement of aging research and the development of strategies to promote healthy aging.

In addition, our analysis aims to elucidate the influence of NAD⁺ on immune cell activity and its contribution to age-related immune dysregulation. We also strive to unravel the involvement of NAD⁺ in age-associated pathologies, including neurodegenerative diseases, metabolic disorders, and cardiovascular conditions.

Analysis of Tricarboxylic Acid Cycle Intermediates in Aging

We analyze tricarboxylic acid (TCA) cycle intermediates in aging using various metabolomics approaches. Our techniques allow for the quantification of TCA cycle intermediates, such as citrate, isocitrate, α-ketoglutarate, succinate, fumarate, and malate, in biological samples.

By studying TCA cycle intermediates in aging, we help our clients gain a better understanding of the metabolic changes that occur with age and their impact on cellular function and health. Our specialized services focus on the analysis of TCA cycle intermediates in specific tissues or organs known to be affected by aging, such as brain tissue, skeletal muscle, or adipose tissue.

Our Service Features

• Metabolite profiling. We utilize analytical techniques to quantify and profile mitochondrial metabolites, including NAD⁺ and TCA cycle intermediates. Our high-throughput approaches ensure reliable measurements, allowing for a detailed analysis of metabolic changes associated with aging.
• Aging models. We provide a wide range of aging models, such as nematodes and mice, to investigate the impact of mitochondrial metabolites on aging. We help our clients select appropriate models considering their strengths and limitations.
• Gene expression analysis. In addition to metabolite profiling, we offer gene expression analysis to examine the transcriptional changes associated with mitochondrial metabolite alterations. Our comprehensive approach allows for a better understanding of the molecular mechanisms underlying aging processes.

CD BioSciences offers comprehensive services and solutions for researchers interested in studying these metabolites and their impact on aging. With our expertise and commitment to quality, we aim to support and advance aging research, ultimately contributing to the development of interventions and treatments for age-related diseases. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Moindjie H, et al. Mitochondrial Metabolism in Carcinogenesis and Cancer Therapy. Cancers (Basel), 2021, 13 (13): 3311.