Epigenetic regulation plays a crucial role in aging, influencing how genes are expressed without altering the underlying DNA sequence. Epigenetic drugs represent a pioneering approach in anti-aging research, with the potential to modify the biological mechanisms underlying aging and age-related diseases.
Fig. 1 An overview of the aging epigenome. (Wang K, et al., 2022)
CD BioSciences specializes in helping clients develop epigenetic drugs with anti-aging effects. Our expertise spans several key areas, including DNA methyltransferase inhibitors, histone deacetylase inhibitors, sirtuin activators, and microRNA therapeutics.
CD BioSciences helps clients develop DNMT inhibitors with anti-aging effects. We focus on identifying potent and selective inhibitors to target DNA methylation associated with aging. Our approach begins with screening various DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B, utilizing high-throughput screening (HTS) techniques to evaluate the candidate's efficacy. Additionally, we apply advanced bioinformatics to perform structure-activity relationship (SAR) analysis, guiding the optimization of lead candidates. Through our rigorous validation processes, we assess the biological impact of these inhibitors on gene expression changes, cellular proliferation, and apoptosis.
CD BioSciences employs advanced synthetic methodologies to develop novel histone deacetylase (HDAC) inhibitors to alleviate the effects of aging and aging-related diseases. Our experts help clients uncover novel candidates that exhibit HDAC inhibitory activity. Following initial screenings, we perform detailed kinetic studies and mechanism of action investigations to delineate how drug candidates interact with the HDAC enzyme family. Furthermore, we conduct extensive in vitro and in vivo assessments to explore the impact of HDAC inhibitors on aging-related disease models. Our services include profiling alterations in gene expression, epigenetic marks, and resultant phenotypic effects.
Sirtuins, a family of NAD+-dependent deacetylases, play pivotal roles in regulating aging processes. CD BioSciences helps clients identify small molecules that effectively enhance sirtuin functions. Our experts combine virtual screening, high-throughput assays, and biochemical analyses to identify promising sirtuin activators with anti-aging effects. We also employ cellular models to examine the biological effects of these activators on metabolic pathways and stress responses, with a particular focus on AMPK, NF-κB, and mTOR due to their significant implications for healthy aging.
MicroRNAs (miRNAs) have emerged as vital regulators of aging. Our process begins with profiling miRNA expression in aging models to identify signature miRNAs. Developing miRNA mimics and inhibitors, we help clients evaluate their effects on target gene regulation and associated aging and aging-related diseases. Our services include functional assays, phenotypic evaluations, and efficacy assessments, establishing a comprehensive analysis for each candidate. Additionally, we emphasize the importance of pharmacokinetics and delivery mechanisms to help clients determine whether miRNA therapeutics are effective and safe.
CD BioSciences is dedicated to helping clients develop epigenetic drugs as anti-aging therapeutics. We provide an integrated suite of services, covering the entire drug discovery process from initial screening to preclinical development. If you are interested in our services, please feel free to contact us or make an online inquiry.
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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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