MicroRNA Therapeutics Discovery Services

MicroRNAs (miRNAs) are small, non-coding RNA molecules that are crucial in regulating gene expression. Their significance in various biological processes, including development, differentiation, and apoptosis, has led to an increased interest in their potential therapeutic applications. During aging, significant changes in miRNA expression profiles have been observed across various organisms, including humans, mice, and other model species. MicroRNAs have emerged as vital regulators of aging, influencing pathways associated with cellular stress responses, inflammation, and metabolic processes.

Fig. 1 Human ortholog of miRNAs (and miRNA families) that directly regulate lifespan in the model organisms Caenorhabditis elegans, Drosophila, and mouse. (Kinser HE and Pincus Z, 2020)

With decades of experience in biotechnology and molecular biology, CD BioSciences offers comprehensive miRNA therapeutic discovery services to advance the development of anti-aging drugs.

How Do We Help Clients Develop MicroRNA Therapeutics?

Identification of miRNA signatures

The first step in developing effective therapeutics involves identifying miRNA signatures associated with specific aging-related diseases. CD BioSciences employs advanced bioinformatic tools and high-throughput sequencing technologies to analyze anti-aging miRNA expression profiles. Through comprehensive validation studies, we help clients identify miRNAs that exhibit consistent expression patterns correlated with aging and aging-related diseases.

MicroRNA therapeutics development

The development of miRNA therapeutics can be categorized into two primary strategies: miRNA inhibition and miRNA replacement.

• MiRNA inhibition. We assist clients in downregulating the activity of miRNAs that contribute to aging by using antisense oligonucleotides (ASOs) or small molecule inhibitors.
• MiRNA replacement. We offer miRNA replacement strategies that involve delivering synthetic miRNAs to replenish those that are deficient in aging tissues. Our services have shown promise in reversing age-related declines in tissue function.

Pharmacokinetics/pharmacodynamics analysis services

CD BioSciences provides comprehensive pharmacokinetics (PK) and pharmacodynamics (PD) analysis services to examine the effectiveness and safety of miRNA therapeutics. We offer comprehensive analysis services to assess the absorption, distribution, metabolism, and excretion (ADME) of miRNA therapeutics. We also help clients evaluate the therapeutic potential and safety profiles of miRNA therapeutics through in vitro and in vivo studies.

Analysis of the Effects of MicroRNA Therapeutics on Aging Tissues

• Analysis of the effects of miRNAs in the aging brain. Specific miRNAs are significantly involved in neurodegenerative diseases. We focus on helping clients develop therapeutics that target these pathways, enabling novel interventions to combat age-related cognitive decline.
• Analysis of the effects of miRNAs in aging muscle. Various miRNAs have been shown to regulate muscle hypertrophy and regeneration. We help clients develop inhibitors for detrimental miRNAs to promote muscle growth while employing miRNA replacement approaches to restore normal muscle homeostasis.
• Analysis of the effects of miRNAs in aging bone. Bone density and strength decrease with age, which is largely attributed to imbalances in the regulation of osteoblast and osteoclast activity governed by miRNAs. We provide customized services to investigate these pathways, empowering our clients to develop effective interventions for maintaining skeletal integrity in the elderly.

CD BioSciences offers comprehensive discovery services ranging from miRNA identification to pharmacological assessment. Through innovative approaches and a deep understanding of the miRNA, we dedicate our efforts to helping clients develop miRNA therapeutics that can prolong life and improve the quality of life in the elderly. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Kinser HE, Pincus Z. MicroRNAs as modulators of longevity and the aging process. Hum Genet, 2020, 139 (3): 291-308.
2. Christopher AF, et al. MicroRNA therapeutics: Discovering novel targets and developing specific therapy. Perspect Clin Res, 2016, 7 (2): 68-74.