Sirtuin Activator Discovery Services

Sirtuins, particularly SIRT1, SIRT2, and SIRT3, are integral to various cellular functions, including DNA repair, metabolism, and inflammation reduction. Research has shown that sirtuin activation can improve mitochondrial function, enhance stress resistance, and increase cellular longevity. Moreover, evidence suggests that sirtuin activators may improve resistance to oxidative stress, a significant contributor to aging. By modulating pathways related to oxidative stress and inflammation, sirtuins help maintain cellular homeostasis, thus promoting healthier aging processes.

Fig. 1 Outline of sirtuin-activating compound (STAC) effects on aging and age-related diseases. (Hubbard BP and Sinclair DA, 2014)

CD BioSciences specializes in providing reliable discovery services to help clients identify and develop sirtuin activators, facilitating breakthroughs in anti-aging research and therapeutics.

Overview of Our Sirtuin Activator Discovery Services for Promoting Healthy Aging

Screening of natural sirtuin activators

Through extensive screening of botanicals, compounds, and other natural products, we identify candidate molecules that can effectively stimulate sirtuin activity. Our methodologies include high-throughput screening assays that evaluate the ability of these compounds to enhance sirtuin deacetylase activity in vitro. Our experts help clients identify potential sirtuin activators with anti-aging effects and elucidate their mechanisms of action.

Synthesis of small molecule activators of sirtuins

CD BioSciences also excels in designing and synthesizing small molecule activators of sirtuin with anti-aging effects. Our experienced medicinal chemistry team utilizes structure-based drug design and structure-activity relationship (SAR) studies to develop potent and selective activators.

In vitro and in vivo studies

CD BioSciences conducts comprehensive in vitro and in vivo studies to validate the efficacy and safety of sirtuin activators. We offer in vitro assays to assess the biological activity of sirtuin activators in various cell lines, allowing us to measure their impact on cell proliferation, apoptosis, and metabolic pathways. Employing techniques such as Western blotting and qPCR, we provide our clients with quantitative and qualitative data on the efficacy of sirtuin activators.

Moreover, our experts help clients conduct in vivo studies to assess the effect of sirtuin activators in aging animal models, evaluating parameters such as metabolic health and tissue function. We track the lifespan of the animal models by recording the date of birth, health status, and causes of death. We also help evaluate the pharmacodynamics and pharmacokinetics of sirtuin activators.

Analysis of the Sirtuin Pathway in Aging

At CD BioSciences, we provide detailed analyses of the key downstream signaling pathways that sirtuin activation influences. We employ advanced proteomics and genomics techniques to analyze the downstream effects of sirtuin activation. By investigating pathways such as AMPK, NF-κB, and mTOR, we can map out how these activators impact cellular health and longevity. By elucidating these pathways, we provide our clients with a comprehensive understanding of how their compounds can influence cellular and systemic processes.

Through our expertise in natural product screening, small molecule synthesis, and detailed mechanistic studies, CD BioSciences is committed to advancing the discovery of sirtuin activators as anti-aging interventions. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci, 2014, 35 (3): 146-54.