In Vitro Anti-Aging Pharmacology Services

The demand for effective anti-aging therapeutics has surged recently, driven by an aging population and a growing interest in longevity. In vitro pharmacology plays a crucial role in developing and evaluating anti-aging drugs. In vitro studies provide a controlled environment, allowing for precise modulation of experimental conditions. This is essential for understanding how different compounds interact with cellular pathways and contribute to anti-aging. Moreover, the ability to test multiple drug candidates in various cell lines accelerates drug discovery, ultimately leading to more effective anti-aging therapies.

CD BioSciences specializes in providing comprehensive in vitro anti-aging pharmacology services, enabling our clients to explore innovative therapeutics that target aging at the cellular level. Our services are tailored to meet the specific needs of clients.

Overview of Our In Vitro Anti-Aging Pharmacology Services

Cellular senescence model customization services

Our team works closely with clients to customize cellular senescence models that reflect specific aging features. Whether utilizing primary human cells or established cell lines, our models are designed to simulate the aging process, helping clients test the efficacy of anti-aging drug candidates.

Assessment of in vitro anti-aging activities

We assist clients in rigorously testing a variety of drug candidates on selected cell lines. By systematically evaluating their impact on cells, we help clients collect robust data using various techniques to uncover the potential of these drug candidates as viable anti-aging therapeutics.

• Cell viability assays. We offer MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and Alamar blue assays to evaluate cell viability in response to anti-aging drugs, providing quantitative data on drug efficacy.
• Cell proliferation assays. We offer a range of cell proliferation assays that cater to different research objectives, including DNA synthesis and metabolic cell proliferation assays. We also employ a variety of dye labels to assess cell proliferation, such as 3H-thymidine, BrdU, MTT, XTT, MTS, WST1, and WST8. Our services are vital for understanding the impact of anti-aging drugs on cellular health and vitality.
• Telomere length measurement. We help clients measure telomere length in treated and untreated cells with quantitative PCR and other techniques. Our services help determine how drug candidates influence telomere dynamics.
• Telomerase activity assay. We also assess telomerase activity, the enzyme responsible for extending telomeres. We assist clients in understanding how drug candidates modulate telomerase activity to reveal drugs' potential for promoting cellular longevity.
• Oxidative stress detection. We employ fluorescence-based assays to quantify ROS levels in cells exposed to anti-aging drugs. Our data helps assess the antioxidant potential of drug candidates. We also assess the activity of key antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, to understand the cellular response to oxidative stress using anti-aging drugs.
• DNA damage assessment. We help clients measure DNA strand breaks and lesions in cells treated with anti-aging drugs. Through Western blotting and qPCR, we analyze the expression and activity of key DNA repair proteins, helping clients understand how drug candidates may enhance the cellular repair response.

Why Choose Us?

• Customized anti-aging pharmacology solutions
• Experienced pharmacology team
• Comprehensive anti-aging drug development support

CD BioSciences is a reliable partner for in vitro anti-aging drug development. Our team of scientists possesses extensive knowledge of pharmacology and cellular biology, enabling us to deliver meaningful results to our clients. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Vaiserman AM, et al. Anti-aging pharmacology: Promises and pitfalls. Ageing Res Rev, 2016, 31: 9-35.