Fish represent about half of all vertebrate species, but have received little attention as models for aging research compared to invertebrates or rodents. However, the basic gerontological characteristics of several fish species have been studied and provide compelling data for further investigation. In particular, guppies have proven to be an invaluable model for evolutionary analyses of aging, killifish are short-lived and can be used for lifespan manipulation studies, and zebrafish have an impressive array of associated biological tools from their widespread use as a model of vertebrate development. These fish are well suited for the study of fundamental processes involved in aging, such as insulin signaling, oxidative stress, and comparative studies of species with widely divergent lifespans.
As a reliable provider of fish model customization services, CD BioSciences is proud to empower our clients to explore the frontiers of aging research. Our team of seasoned experts leverages the unique advantages of diverse fish species to uncover novel insights that can profoundly shape our understanding of the aging process.
The remarkable killifish, with its exceptional lifespan of just a few months, has emerged as a premier model for aging research. Our skilled scientists work closely with clients to customize killifish models, tailoring lifespan modulation, age-related phenotype analyses, genetic modifications, and behavioral analysis to meet the goal of research. Harnessing the accelerated aging timeline of the killifish, our clients can help clients rapidly acquire data and insights that would take significantly longer in other model organisms.
We collaborate with clients to develop customized guppy models that reveal the intricate interplay between genetics, environment, and the aging process. From lifespan studies to the study of age-related physiological changes, our guppy model customization services help clients make discoveries. Additionally, our guppy model customization services for aging research include comprehensive behavioral assessments to uncover the effects of aging on various aspects of guppy behavior, such as foraging strategies, locomotor activity, metabolic rate, and cognitive function.
The versatile zebrafish has long been a staple in aging research, and CD BioSciences is proud to offer a suite of zebrafish model customization services. Our services involve manipulating the aging process, genetic modification, and analyzing age-related phenotypes in zebrafish models. We also help clients develop customized disease models, from neurodegenerative to cardiovascular, that recapitulate the age-dependent onset and progression of various pathologies. In addition, our customized zebrafish model has the potential to help clients accelerate drug discovery and development, particularly in aging-related diseases.
At the heart of CD BioSciences' fish model customization services lies a deep dedication to the analysis of aging biomarkers. In addition to senescence-associated β-galactosidase (SA-β-gal) and telomere length, another key aging biomarker that CD BioSciences closely monitors in our fish models is the accumulation of lipofuscin, a complex mixture of oxidized proteins, lipids, and metals that accumulates in cells over time. Using advanced microscopy techniques, such as confocal and multiphoton imaging, we help clients quantify the accumulation of lipofuscin granules in various cell types and tissues within our customized fish models.
By integrating our fish model customization services with advanced analytical tools, CD BioSciences empowers our clients to make progress in aging research. If you are interested in our services, please feel free to contact us or make an online inquiry.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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