Customization of Guppy (Poecilia reticulata) Models for Aging Research

Aging functions as a primary risk factor for numerous chronic diseases through its effects, which result in physiological deterioration and homeostatic imbalance. Small teleost fish are now serving as animal models in aging research due to their genetic structures and organs, which show strong similarities to human systems. The guppy (Poecilia reticulata) lives for fewer years compared to the zebrafish because they share the category of small teleost fish. Guppies can be easily maintained because they reproduce rapidly and need no special equipment or facilities.

With extensive experience in aging research, CD BioSciences offers comprehensive customization services for the guppy models. Our services are aimed at unveiling the complex mechanisms of aging using this versatile and invaluable model organism.

Our Guppy Model Customization Options for Aging Research

Genetic modification of guppy models

We provide customization services for guppy models with genetic modification to elucidate aging-related pathways and genes. Our expertise in gene editing enables the guppy models with tailored genetic alterations, allowing clients to study the impact of specific genes on the aging process. By incorporating gene knock-in, knock-out, or editing strategies, we empower clients to accelerate anti-aging drug discovery and development.

Lifespan studies in guppy models

The relatively short lifespan of guppy makes it an ideal model for longitudinal studies on the determinants of longevity. We employ tracking and monitoring systems to observe and record the lifespan of our customized guppy models. By analyzing factors such as dietary interventions, environmental conditions, and genetic modifications, we can elucidate the complex interplay between various factors and their impact on lifespan.

Behavioral aging analysis of guppy models

Our guppy model customization services for aging research include comprehensive behavioral assessments to uncover the effects of aging on various aspects of guppy behavior, such as foraging strategies, locomotor activity, metabolic rate, and cognitive function. We provide services to help clients shed light on the neurological and behavioral hallmarks of the aging process, ultimately informing the development of targeted interventions.

Applications of Guppy Models for Studying the Evolutionary Biology of Aging

Guppy models offer a unique opportunity to explore the evolutionary aspects of aging. CD BioSciences supports research aimed at investigating the evolutionary biology of aging using guppy models as a versatile experimental system.

• Uncovering adaptive strategies for longevity. Guppies exhibit remarkable variation in lifespan and aging-related traits across their natural populations. We provide services to help clients uncover the selective pressures and adaptive strategies that have shaped the evolution of longevity over generations.
• Investigating the genetic basis of aging-related traits. Leveraging techniques such as genome-wide association studies (GWAS) and quantitative trait locus (QTL) mapping, we can pinpoint the specific genomic regions and candidate genes that contribute to the observed variations in guppy longevity. We also employ advanced epigenomic profiling techniques, such as DNA methylation analysis and histone modification mapping, to track the epigenetic signatures associated with different stages of the guppy life cycle.

At CD BioSciences, our guppy model customization services for aging research offer an unparalleled opportunity to unlock the secrets of the aging process. If you are interested in our services, please feel free to contact us or make an online inquiry.

References

1. Imai M, et al. The guppy (Poecilia reticulata) is a useful model for analyzing age-dependent changes in metabolism, motor function, and gene expression. Exp Gerontol, 2022, 160: 111708.
2. Reznick DN. Life history evolution in guppies (Poecilia reticulata): guppies as a model for studying the evolutionary biology of aging. Exp Gerontol, 1997, 32 (3): 245-58.