With the increase in human life expectancy and the aging of the population, there has been an increase in the study of aging-related neurodegenerative diseases. The use of animal models of aging has also increased. Animal and cell models are commonly used in aging research to study longevity and aging-related diseases due to their relatively short lifespan compared to humans. These studies help researchers understand the underlying molecular mechanisms of aging and develop potential interventions.
Fig. 1 Brain aging hallmarks and neurological diseases. (Azam S, et al., 2021)
As a reliable provider of aging research solutions, CD BioSciences is committed to offering our clients customized model services to propel their aging-related neurodegenerative disease research forward.
At CD BioSciences, we offer highly customized Alzheimer's disease models that can be tailored to the specific research needs of our clients, including but not limited to mice, rats, non-human primates (NHPs), Caenorhabditis elegans, induced pluripotent stem cell (iPSC)-derived cell lines, and human neuroblastoma cell lines. Our models incorporate advancements in genetic engineering, cellular biology, and biochemical analysis, allowing clients to investigate the complex pathways and mechanisms underlying these debilitating diseases. Whether investing the role of amyloid-beta accumulation, tau protein aggregation, or neuroinflammation, our skilled team can develop custom Alzheimer's disease models to provide clients with relevant and reliable data.
We provide customization services for Parkinson's disease models, such as rodents, NHPs, C. elegans, and yeasts. Our services involve advanced genetic engineering, neurochemistry, and behavioral analysis, enabling clients to investigate the complex interplay between environmental factors, genetic predispositions, and neuronal degeneration. In addition, our team of expert scientists has developed a comprehensive suite of analysis services to elucidate how the aging process affects Parkinson's disease by analyzing neurodegeneration, pathological changes, and changes in the dopaminergic system.
At CD Biosciences, we use a range of approaches to help our clients develop customized Huntington's disease models that display key features of the disease. Additionally, our team has extensive expertise in developing Drosophila melanogaster and C. elegans models that exhibit age-dependent Huntington's disease-like symptoms. Furthermore, we offer customization services to clients with cell models, including HEK-293 and nerve cell lines.
We offer customization services to help clients generate several models to study amyotrophic lateral sclerosis (ALS) pathology, including both in vivo and in vitro models. Although these models have different characteristics, they are all useful and complementary. Our models put forward the studies of the role of SOD1, FUS, and C9orf72 mutations, and TDP-43 aggregation. Additionally, we assist clients in exploring the biological mechanisms underlying the association between aging and ALS, including the study of age-related changes in motor neuron function, genetic mutations associated with both aging and ALS, and the impact of cellular aging processes on the development or progression of ALS.
Leveraging our expertise and facilities, CD BioSciences provides our clients with reliable aging-related neurodegenerative disease models. If you are interested in our services, please feel free to contact us or make an online inquiry.
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CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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