Alzheimer's disease (AD) is a complex disease with multiple contributing factors. Aging is the most profound risk factor for Alzheimer's disease and many other non-infectious diseases. The hallmarks of Alzheimer's disease in the brain are the extracellular accumulation of amyloid β (Aβ) into plaques, including in blood vessels, and intraneuronal accumulation of abnormally phosphorylated tau, forming neurofibrillary tangles. Experimental models of Alzheimer's disease are critical for understanding the disease pathogenesis and evaluating potential new therapies.
Fig. 1 Schematic of the major animal models of Alzheimer's disease. (Drummond E and Wisniewski T, 2017)
CD BioSciences offers a full suite of in vitro and in vivo Alzheimer's disease model customization services to facilitate innovative research in aging and neurodegeneration. Our team of seasoned experts harnesses the power of advanced model systems to unlock the complexities of this debilitating neurodegenerative disorder, with a particular focus on the unique challenges posed by the aging process.
Induced pluripotent stem cells (iPSCs) have revolutionized the field of disease modeling by enabling the generation of patient-specific cell lines for studying Alzheimer's disease. We provide expertise in generating iPSCs-derived neuronal cell lines harboring Alzheimer's disease-associated genetic mutations, allowing clients to investigate the mechanism of aging-associated diseases and drug screening at the cellular level.
We offer customized Alzheimer's disease models using human neuroblastoma cells, providing clients with a versatile tool for investigating molecular pathways, protein aggregation, and neurotoxicity associated with Alzheimer's disease.
For clients interested in taking advantage of the unique benefits of invertebrate model systems, CD BioSciences offers customized C. elegans models of Alzheimer's disease. These simple yet informative models allow for rapid, high-throughput screening of potential therapeutics and exploring fundamental cellular and molecular mechanisms underlying Alzheimer's disease pathogenesis. Our team can engineer C. elegans strains to harbor specific gene mutations or overexpression patterns, allowing for the investigation of age-related changes in the context of this versatile model organism.
CD BioSciences has an extensive repertoire of customized transgenic mouse models that recapitulate the hallmarks of Alzheimer's disease. Our scientists can tailor these models to faithfully mimic disease progression in aging populations, incorporating key genetic and environmental factors that influence disease onset and severity. Below is a selection of our transgenic mouse models.
| Mouse models | Mutations |
| PDAPP, Tg2576, APP23, J20, APP/PS1, TgSwDI, TgF344-AD, SAPP, 3xTg, 5xFAD | APPV717F, APPV716V, APPK670N, M671L, PSEN1L166P, PSEN1M146L, PSEN1ΔE9, APPE693Q, APPD694N, APPE693Δ, PSEN1M146V, PSEN1M146L, PSEN1L286V |
We also offer transgenic rat models of Alzheimer's disease that allow for more in-depth investigations of cognitive impairment, neuroinflammation, and other age-related comorbidities. Our team can customize these models to incorporate specific genetic modifications, ensuring that they faithfully reflect the unique challenges of aging in the context of Alzheimer's disease.
NHPs are evolutionarily closer to humans compared to rodents, providing a more relevant biological model. We can offer NHP models of Alzheimer's disease, including various species of Old World monkeys (e.g., rhesus monkeys, cynomolgus monkeys, baboons, and vervets). Our models closely mimic the pathological and behavioral features observed in human patients, including the progressive cognitive decline associated with aging. Our experts work closely with clients to tailor these models to their specific research needs, leveraging the power of these valuable animal systems to advance the understanding and treatment of Alzheimer's disease.
Customizing Alzheimer's disease models is essential for advancing our understanding of disease mechanisms and developing effective therapeutic strategies. At CD BioSciences, our expertise in providing in vitro and in vivo Alzheimer's disease model customization services to delve deeper into the complexities of Alzheimer's disease. If you are interested in our services, please feel free to contact us or make an online inquiry.
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CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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