ZBTB24 (E5D6G) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0628

Target Information
UniProt ID	O43167

Product Details
Size	100 µL
Reactivity	Human, Mouse, Rat, Monkey
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro569 of human ZBTB24 protein.

Usage
Application	WB, IP, ChIP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:100); Chromatin IP (1:100)
MW (Target)	95 kDa

Background
Zinc finger and BTB domain-containing protein 24 (ZBTB24), also called ZNF450, is a DNA-binding protein initially found to be expressed in response to BMP-2 signaling ZBTB24 along with CDCA7 play a role in DNA methylation by recruiting the HELLS chromatin remodeling complex to centromeric satellite repeats Mutations in ZBTB24 are linked to immunodeficiency and centromeric instability, and facial anomalies syndrome type 2 (ICF2) ZBTB24 is recruited to DNA breaks by PARP1 and promotes assembly of the LIG4/XRCC4 complex, resulting in error free non-homologous end joining (NHEJ) ZBTB24 has also been shown to play a role in trophoblast proliferation through the methylation of E-cadherin.

Background

Zinc finger and BTB domain-containing protein 24 (ZBTB24), also called ZNF450, is a DNA-binding protein initially found to be expressed in response to BMP-2 signaling ZBTB24 along with CDCA7 play a role in DNA methylation by recruiting the HELLS chromatin remodeling complex to centromeric satellite repeats Mutations in ZBTB24 are linked to immunodeficiency and centromeric instability, and facial anomalies syndrome type 2 (ICF2) ZBTB24 is recruited to DNA breaks by PARP1 and promotes assembly of the LIG4/XRCC4 complex, resulting in error free non-homologous end joining (NHEJ) ZBTB24 has also been shown to play a role in trophoblast proliferation through the methylation of E-cadherin.

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