Zap-70 (L1E5) Mouse Antibody
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Zap-70 (L1E5) Mouse Antibody

INQUIRY

CAT. NO.: AMA-0339

Target Information
UniProt ID P43403
Product Details
Size 100 µL
Reactivity Human
Host Mouse
Source/Isotype Mouse IgG1
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the Ser289 of human Zap-70.
Usage
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target) 70 kDa
Background
The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia.

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