CAT. NO.: AMA-0474
| Target Information | |
|---|---|
| UniProt ID | P43403 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino-terminus of human Zap-70. |
| Usage | |
|---|---|
| Application | WB, IP, IHC, F |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50); Immunohistochemistry (1:200 -1:800); Flow Cytometry (1:200-1:800) |
| MW (Target) | 70 kDa |
| Background | |
|---|---|
| The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia. | |
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