CAT. NO.: ABS-074
| Product Details | |
|---|---|
| Alternate Name | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one |
| CAS Number | 284028-89-3 |
| Molecular Formula | C14H11F3N2OS |
| Molecular Weight | 312.31 |
| Appearance | White solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (50 mM) |
| SMILES | C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F |
| PubChem CID | 2726824 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. | |
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