WIP1 (E2X1I) Rabbit Antibody
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WIP1 (E2X1I) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0274

Target Information
UniProt ID O15297
Product Details
Size 100 µL
Reactivity Human
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly383 of human WIP1 protein.
Usage
Application WB, IP, IF
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:800-1:3200)
MW (Target) 79 kDa
Background
Wild-type p53 induced phosphatase 1 (WIP1)/protein phosphatase magnesium-dependent 1 delta (ppm1d) is a member of the PP2C family of serine/threonine protein phosphatases. WIP1 was initially identified as a p53 target gene, induced in response to ionizing radiation. Studies have shown that WIP1 is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways. WIP1 functions in returning cells to a homeostatic state following DNA damage, as well as in maintaining p53-dependent homeostasis under non-stressed conditions. Researchers have shown that increased expression of WIP1 is associated with poor prognosis and lower survival rate in some human cancers. In contrast, overexpression of WIP1 in p53-negative tumor cells sensitizes them to chemotherapy-induced apoptosis while protecting normal tissue during treatment.

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