UNC5B (D9M7Z) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0562

Target Information
UniProt ID	Q8IZJ1

Product Details
Size	100 µL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly420 of human UNC5B protein.

Usage
Application	WB, IP
Product Usage Information Dilution	Western Blotting (1:2000); Immunoprecipitation (1:50)
MW (Target)	130 kDa

Background
Netrin proteins belong to an evolutionarily conserved family of laminin-like molecules that are involved in axon guidance and vascular development. These secreted proteins can have opposing functions depending on specific receptor association. For example, deleted in colorectal cancer (DCC) family receptors typically mediate cellular attraction while netrin bound to UNC5 family receptors induce cellular repulsion The uncoordinated 5B homolog (UNC5B) is a transmembrane protein with extracellular Ig-like domains and an intracellular region containing a protein-binding death domain and a putative DCC interaction domain Homodimers composed of DCC receptor proteins mediate axonal attraction responses, while UNC5B homodimers and UNC5B-DCC heterodimers promote cellular repulsion The netrin receptor UNC5B mediates apoptosis in the absence of netrin through the activation of DAP kinase and is involved in leukocyte migration inhibition Expression of UNC5B correlates with bladder cancer stage and the receptor is a potential predictor of both bladder and colorectal cancer prognosis and possible disease recurrence.

Background

Netrin proteins belong to an evolutionarily conserved family of laminin-like molecules that are involved in axon guidance and vascular development. These secreted proteins can have opposing functions depending on specific receptor association. For example, deleted in colorectal cancer (DCC) family receptors typically mediate cellular attraction while netrin bound to UNC5 family receptors induce cellular repulsion The uncoordinated 5B homolog (UNC5B) is a transmembrane protein with extracellular Ig-like domains and an intracellular region containing a protein-binding death domain and a putative DCC interaction domain Homodimers composed of DCC receptor proteins mediate axonal attraction responses, while UNC5B homodimers and UNC5B-DCC heterodimers promote cellular repulsion The netrin receptor UNC5B mediates apoptosis in the absence of netrin through the activation of DAP kinase and is involved in leukocyte migration inhibition Expression of UNC5B correlates with bladder cancer stage and the receptor is a potential predictor of both bladder and colorectal cancer prognosis and possible disease recurrence.

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