Tuberin/TSC2 (D57A9) Rabbit Antibody
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Tuberin/TSC2 (D57A9) Rabbit Antibody

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CAT. NO.: AMA-0561

Target Information
UniProt ID P49815
Product Details
Size 100 µL
Reactivity Human, Mouse, Rat
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues of human tuberin.
Usage
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target) 200 kDa
Background
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors Tuberin is directly phosphorylated at Thr1462 by Akt/PKB Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.

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