CAT. NO.: ABH-029
| Product Details | |
|---|---|
| Alternate Name | n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide |
| CAS Number | 1239262-52-2 |
| Molecular Formula | C20H21N3O2.HCl |
| Molecular Weight | 371.86 |
| Appearance | Off-white solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (90 mg/mL) or Water ( 4mg/mL) or 2% TWEEN-80/water (2 mg/mL) |
| SMILES | CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl |
| PubChem CID | 57336514 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 µM with near complete protection at 10 µM. | |
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