Toxicokinetics Studies for Anti-Aging Drug Development

Toxicokinetics (TK) studies the absorption, distribution, metabolism, and excretion (ADME) of drugs, providing critical insights into how a drug behaves within the body over time. Understanding toxicokinetics is essential for anti-aging drugs to ensure safety and optimize therapeutic dosing. Anti-aging drugs must be rigorously tested to determine their safety. This includes identifying potential toxic effects that may result from long-term use or interactions with other drugs.

CD BioSciences offers specialized toxicokinetics studies to support the development of anti-aging drugs. Our services are designed to help clients mitigate the risk associated with adverse effects.

Overview of Our Toxicokinetics Studies for Anti-Aging Drug Development

CD BioSciences offers a comprehensive suite of toxicokinetics studies tailored specifically for anti-aging drug development. Our services include the selection of appropriate animal models, the study of different types of toxicity, the determination of the optimal route of administration, and sample collection. We offer various animal models to help clients conduct toxicokinetics studies, including mice, rats, rabbits, dogs, pigs, and non-human primates. Additionally, we assist in elucidating drug metabolite profiles and structures in a range of biological matrices, including whole blood, urine, and tissues.

We provide toxicokinetics services focused on describing the behavior of anti-aging drugs in the body.

• Absorption. We assess the rate and extent of drug absorption following various routes of administration.
• Distribution. We evaluate the distribution of the drug in different tissues and organs.
• Metabolism. We identify and quantify the metabolites produced and the enzymes involved in their formation.
• Excretion. We determine the routes and rate of drug elimination from the body.

What Toxicokinetic Parameters Do We Measure?

CD BioSciences specializes in measuring several key toxicokinetic parameters that provide insights into the dynamic behavior of drugs in biological systems, including maximum concentration (C_max), time to reach C_max (T_max), area under the curve (AUC), half-life (t_1/2), clearance (CL), and volume of distribution (VD). Our team also utilizes advanced statistical methods to rigorously analyze data.

Technical Tools Used in Toxicokinetics Studies

CD BioSciences leverages advanced technologies and methodologies to help clients conduct toxicokinetics studies.

High-performance liquid chromatography (HPLC)

We use HPLC to accurately quantify drug concentrations in biological samples. Our technique provides reliable data critical to all phases of toxicokinetic studies.

Liquid chromatography-mass spectrometry (LC-MS)

We use LC-MS for detailed analysis of drug metabolism. We help clients identify and quantify metabolites to gain insights into the metabolic pathways of drugs and potential toxic effects.

Pharmacokinetic software

Based on experimental data, we employ advanced pharmacokinetic modeling software to simulate and predict the dynamic behavior of drugs. Our services assist clients in refining study designs and optimizing dosing strategies.

CD BioSciences is committed to providing comprehensive and tailored toxicokinetics studies to ensure that clients can confidently navigate the challenges of developing safe and effective anti-aging therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.