CAT. NO.: ABM-020
| Product Details | |
|---|---|
| Alternate Name | 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one |
| CAS Number | 1223001-51-1 |
| Molecular Formula | C24H15F3N4O |
| Molecular Weight | 432.4 |
| Appearance | Yellow solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (8 mg/mL) |
| SMILES | C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F |
| PubChem CID | 51358113 |
| Handling | Protect from air and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to 440 other protein kinases. | |
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