CAT. NO.: AMA-0336
| Target Information | |
|---|---|
| UniProt ID | Q96CG3 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro159 of human TIFA protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 21 kDa |
| Background | |
|---|---|
| TRAF-interacting protein with FHA domain-containing protein A (TIFA) is a cytosolic adaptor protein that is a critical node in an innate immune signaling axis that is activated upon detection of proinflammatory stimuli derived from a bacterial pathogen-associated molecular pattern metabolite, ADP-heptose ADP-heptose binds and activates Alpha-protein kinase 1, which drives the phosphorylation-dependent oligomerization and activation of TIFA Activated TIFA is then poised to shape the innate immune response by triggering TRAF6 oligomerization, IKK activation, and NF-κB-dependent proinflammatory gene transcription. | |
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