Telomerase Activator Discovery Services

The relationship between telomerase activity and aging is profound. In most somatic cells, telomerase is inactive, resulting in progressive telomere shortening with each cell division. This process is linked to age-related diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders. Telomerase activators have the potential to reverse or mitigate these effects by extending the functional lifespan of cells. Research indicates that enhancing telomerase activity may lead to improved tissue regeneration and reduced incidence of age-related pathologies.

Fig. 1 Overview of the different functions of the telomere. (Gopenath TS, et al., 2022)

CD BioSciences employs a multifaceted approach to help clients develop telomerase activators and evaluate their anti-aging potential.

How Do We Help Clients Develop Telomerase Activators?

Discovery of potent telomerase activators

At CD BioSciences, we begin telomerase activator discovery services with a thorough screening process. We provide high-throughput screening services that allow clients to evaluate thousands of natural and synthetic drug candidates for their ability to increase telomerase activity. We help clients efficiently identify promising candidates using advanced automated systems and assay technologies.

Functional assessment of telomerase activators

Once potential telomerase activators have been identified, we conduct a series of assays to validate their efficacy. Our services include:

• Gene expression analysis. We help clients measure gene expression levels associated with telomerase activation to confirm that selected candidates induce telomerase expression. We also employ RNA sequencing to provide a comprehensive view of how telomerase activators alter gene expression profiles in target cells.
• Telomere length analysis. We assess telomere length in treated cells, providing critical data on the effects of drug candidates on telomeres. We also investigate the signaling pathways influenced by telomerase activators to elucidate their mechanisms of action.
• Cell viability and proliferation assays. We evaluate the effects of telomerase activators on cell health and growth, screening that the candidates have no adverse effects on cellular function.

Applications of Telomerase Activators in Aging and Aging-Related Diseases

CD BioSciences offers a range of specialized services to facilitate the discovery and development of telomerase activators for various applications.

• Cellular senescence. Telomerase activators have the potential to reverse or prevent cellular senescence. We offer a variety of senescence assays to measure cellular aging markers, such as beta-galactosidase activity and telomere length to help identify to identify the impact of telomerase activators on senescent cells.
• Aging-related cardiovascular diseases. Telomerase activators play a role in cardiovascular health by protecting cardiac cells from aging. We help clients assess the effects of telomerase activators on cardiac cell health, function, and longevity.
• Aging-related neurodegenerative diseases. CD BioSciences supports the development of telomerase activators for neuron protection. We offer neuronal cell culture services that enable the evaluation of telomerase activators on neuronal viability, morphology, and function.
• Age-related immune dysfunction. Telomerase activators may help maintain immune function. Our immunosenescence assays can determine the effects of telomerase activators on immune cell populations, including T-cell proliferation and cytokine production.

CD BioSciences is dedicated to the development of telomerase activators and offers a full spectrum of services to support the development of anti-aging therapeutics. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Gopenath TS, et al. Telomerase reactivation for anti-aging. Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, 2022, 113-125.