TBK1/NAK (D1B4) Rabbit Antibody (Biotinylated)
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TBK1/NAK (D1B4) Rabbit Antibody (Biotinylated)

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CAT. NO.: AMA-0691

Target Information
UniProt ID Q9UHD2
Product Details
Size 100 µL
Reactivity Human, Mouse, Rat, Monkey
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser645 of human TBK1/NAK protein.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 84 kDa
Background
TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response.

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