CAT. NO.: ABH-026
Product Details | |
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Alternate Name | 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one |
CAS Number | 5690-03-9 |
Molecular Formula | C13H10O2 |
Molecular Weight | 198.2 |
Appearance | White to off-white solid |
Purity | ≥98% |
Solubility | DMSO (100 mg/mL) |
SMILES | C1CC(=O)OC2=C1C3=CC=CC=C3C=C2 |
PubChem CID | 5269 |
Handling | Protect from air and moisture. |
Storage Conditions | 4°C |
Description | |
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Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC50 = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. |
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