Splitomicin
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Splitomicin

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CAT. NO.: ABH-026

Product Details
Alternate Name 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
CAS Number 5690-03-9
Molecular Formula C13H10O2
Molecular Weight 198.2
Appearance White to off-white solid
Purity ≥98%
Solubility DMSO (100 mg/mL)
SMILES C1CC(=O)OC2=C1C3=CC=CC=C3C=C2
PubChem CID 5269
Handling Protect from air and moisture.
Storage Conditions 4°C
Description
Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC50 = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

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