Spatial Omics Services for Aging Research

Spatial omics technology is considered to be another biotechnology research hotspot after single-cell sequencing technology, which mainly includes spatial metabolome, spatial proteome, and spatial transcriptome.

Fig. 1 Outline diagram of the spatial omics approach to profiling the molecular composition and preserving its spatial organization. (Bressan D, et al., 2023)

Spatial omics are invaluable tools for aging research, providing a deep and comprehensive understanding of the molecular and cellular changes that occur with age. CD BioSciences offers a wide range of spatial omics services to help our clients investigate the complex interplay between molecular processes and tissue architecture in aging.

Overview of Our Spatial Omics Services

Spatial transcriptomics profiling in aging

Our spatial transcriptomics services, integrating high-resolution spatial gene expression data with tissue architecture, enable the characterization of age-related changes in gene expression patterns within specific tissue microenvironments. Based on this, we can help our clients understand the spatial distribution of genes associated with aging-related pathways and cellular senescence.

Spatial proteomics analysis in aging

Our spatial proteomics services would focus on mapping the spatial distribution of proteins within aging tissues, allowing for the identification of age-related changes in protein expression, post-translational modifications, and protein-protein interactions. We then use these data to understand spatially regulated signaling networks and age-related changes in protein localization.

Spatial metabolomics profiling in aging

We offer spatial metabolomics services to investigate the spatial distribution of metabolites within aging tissues, offering insights into the metabolic changes associated with aging. So, we shed light on the spatial heterogeneity of metabolic pathways and the impact of aging on regional metabolic signatures within tissues.

Spatial multi-omics integration for aging studies

Our company allows for the integration of spatial transcriptomics, proteomics, and metabolomics data to create a comprehensive spatial molecular atlas of aging tissues. Therefore, we can identify spatially regulated molecular networks and age-related changes across multiple omics layers.

Key Steps in Spatial Omics Services

• Sample preparation and imaging
  We collect samples from people of different ages or animal models of aging. Additionally, obtaining samples from age-matched healthy individuals and those with age-related conditions can enable comparative analyses to identify spatial omics changes specifically associated with aging.
  We employ various techniques, such as cryosectioning or laser capture microdissection, to obtain spatially resolved samples. Next, the samples are imaged using advanced microscopy techniques, such as fluorescence microscopy or mass spectrometry imaging.
• Spatial omic profiling & data analysis
  After imaging, the samples undergo omics profiling to obtain molecular information. We employ techniques such as sequencing, mass spectrometry-based techniques, and fluorescence in situ hybridization to measure molecular expression levels. The data generated from omics profiling are then subjected to comprehensive bioinformatic and computational analyses.

Deliverables for Analyzing Senescence with Spatial Omics

Our platform ensures the confidentiality and security of submitted data. Upon receipt of spatial genomics data, our team of experts will perform in-depth analysis using state-of-the-art algorithms and computational tools.

We provide comprehensive reports detailing the spatial distribution of molecular changes associated with aging, including identified biomarkers, gene expression patterns, and spatial regulatory pathways. These results could serve as a basis for further exploration and validation of potential targets for aging-related therapies.

CD BioSciences offers spatial omics services as a powerful tool for aging research. By combining high-resolution imaging with omics profiling, our services enable clients to unravel the complex spatial organization of biomolecules within tissues and gain valuable insights into the mechanisms of aging. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Bressan D, et al. The dawn of spatial omics. Science, 2023, 381 (6657): eabq4964.