CAT. NO.: ABU-006
| Product Details | |
|---|---|
| Alternate Name | 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid |
| CAS Number | 432001-69-9 |
| Molecular Formula | C18H13BrN2O4S2 |
| Molecular Weight | 465.34 |
| Appearance | Yellow solid |
| Purity | ≥98% by TLC |
| Solubility | DMSO (15 mg/mL) |
| SMILES | BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C\2=O)=S)=C(OCC(O)=O)C=C1 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases. | |
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