CAT. NO.: APE-054
| Product Details | |
|---|---|
| Alternate Name | NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2 |
| Gene Symbol | SIRT2 |
| Gene ID | 22933 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | rh-Sirtuin 2 (SIRT2) with the native N-terminus is supplied as a liquid of 2 mg/ml in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol. |
| Molecular Weight | 43 kDa |
| Purity by SDS-PAGE | ≥90% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Description | |
|---|---|
| Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A. | |
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