CAT. NO.: ABH-021
Product Details | |
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Alternate Name | 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide; Pracinostat |
CAS Number | 929016-96-6 |
Molecular Formula | C20H30N4O2 |
Molecular Weight | 358.48 |
Appearance | Crystalline solid |
Purity | ≥98% |
Solubility | DMSO |
SMILES | CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO |
PubChem CID | 49855250 |
Handling | Protect from light and moisture. |
Storage Conditions | -20°C |
Description | |
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An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg. |
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