SB 939
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SB 939

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CAT. NO.: ABH-021

Product Details
Alternate Name 3-​[2-​butyl-​1-​[2-​(diethylamino)ethyl]-​1H-​benzimidazol-​5-​yl]-​N-​hydroxy-​2E-​propenamide; Pracinostat
CAS Number 929016-96-6
Molecular Formula C20H30N4O2
Molecular Weight 358.48
Appearance Crystalline solid
Purity ≥98%
Solubility DMSO
SMILES CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO
PubChem CID 49855250
Handling Protect from light and moisture.
Storage Conditions -20°C
Description
An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg.

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