CAT. NO.: ABS-061
| Product Details | |
|---|---|
| Alternate Name | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
| CAS Number | 301836-41-9 |
| Molecular Formula | C22H18N4O3 |
| Molecular Weight | 384.39 |
| Appearance | Crystalline solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (20 mg/mL) or EtOH (2 mg/mL) |
| SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| PubChem CID | 4521392 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It inhibits ALK4 only at higher concentrations (IC50 = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway. | |
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