RepSox

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CAT. NO.: ABS-057

Product Details
Alternate Name	2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E-616452
CAS Number	446859-33-2
Molecular Formula	C₁₇H₁₃N₅
Molecular Weight	287.32
Appearance	Off-white solid
Purity	≥98% by HPLC
Solubility	DMSO (>20 mg/mL)
SMILES	CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
PubChem CID	449054
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
Cell-permeable. A TGF-β type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC50 = 4 nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription.

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