CAT. NO.: ABH-018
| Product Details | |
|---|---|
| Alternate Name | (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; Belinostat |
| CAS Number | 414864-00-9 |
| Molecular Formula | C15H14N2O4S |
| Molecular Weight | 318.35 |
| Appearance | White solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>50 mg/mL) |
| SMILES | C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO |
| PubChem CID | 6918638 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent histone deacetylase (HDAC) activity inhibitor. It inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Belinostat significantly increases acetylation of histones H3 and H4 and potently inhibits the growth of prostate cancer cell lines (IC50 range from 0.5 to 2.5 µM) with cytotoxic activity preferentially against tumor cells. | |
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