PS48

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CAT. NO.: ABS-052

Product Details
Alternate Name	(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
CAS Number	1180676-32-7
Molecular Formula	C₁₇H₁₅ClO₂
Molecular Weight	286.75
Appearance	White to off-white solid
Purity	≥95% by HPLC
Solubility	DMSO (100 mM) or EtOH (50 mM)
SMILES	C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl
PubChem CID	44141940
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate, a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.

Description

An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate, a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.

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