Protein Kinase Modulator Discovery Services

The intricate network of protein kinases orchestrates fundamental cellular processes, including cell growth, metabolism, stress response, and apoptosis. Aberrant kinase activity disrupts these processes, contributing to cellular senescence, inflammation, and ultimately the aging phenotype. Modulating the activity of key kinases, either through inhibition or activation, presents a powerful strategy to counteract age-related cellular decline.

Fig. 1 Protein kinase A (PKA) consists of two regulatory subunits, which function to maintain two catalytic subunits in an inactive status. (Gopenath TS, et al., 2022)

CD BioSciences focuses on the identification and development of modulators targeting kinases implicated in aging-related pathways, providing a targeted approach to combat aging-related diseases. Our services encompass an efficient workflow, integrating diverse methodologies to help clients discover and optimize potent and selective protein kinase modulators.

Overview of Our Protein Kinase Modulator Discovery Services

Design of protein kinase modulators

At CD BioSciences, we help clients design novel protein kinase modulators specifically for anti-aging applications. Utilizing advanced computational techniques, we perform molecular modeling and docking studies to predict the interaction of potential modulators with their kinase targets. Our structure-based design approach ensures that protein kinase modulators possess optimal binding affinities and specificities, laying the foundation for successful anti-aging drug development.

High-throughput screening of protein kinase modulators

We use high-throughput screening (HTS) platforms to discover targeted protein kinases from vast drug libraries. Our advanced screening platforms allow thousands of candidates to be tested simultaneously in a variety of cellular assays. Our rapid and efficient process accelerates the identification of potent modulators, significantly reducing the time and resources required to advance to the next stages of development.

Preclinical studies

CD BioSciences supports comprehensive preclinical studies to evaluate the efficacy and safety of selected protein kinase modulators. Our services encompass in vitro assays using relevant cell lines and in vivo studies using appropriate animal models to comprehensively evaluate the effects of protein kinase modulators on relevant aging pathways and phenotypes. We also employ advanced imaging techniques and biomarker analysis to meticulously assess the modulators' effects on longevity, healthspan, and disease progression, using validated markers of aging and aging-related diseases.

How Do We Analyze the Role of Protein Kinase Modulators in Anti-Aging?

CD BioSciences utilizes a combination of biochemical assays, cellular models, and omics technologies to elucidate the mechanisms by which protein kinase modulators exert their effects.

• Biochemical assays. We employ a range of biochemical assays to investigate the activity of protein kinase modulators at the molecular level. Our assays help determine the modulators' effects on kinase phosphorylation states, downstream signaling pathways, and overall cellular responses. We help clients establish a clear link between modulator activity and anti-aging effects.
• Omics technologies. CD BioSciences integrates omics technologies, such as genomics, proteomics, and metabolomics, into our analysis services. Our comprehensive approaches allow clients to profile the effects of protein kinase modulators on cellular systems, identifying biomarkers of aging and potential therapeutic targets.

At CD BioSciences, our expertise in the design, screening, and analysis of protein kinase modulators makes us a reliable partner in anti-aging drug development. If you are interested in our services, please feel free to contact us or make an online inquiry.[

Reference

1. Enns LC, Ladiges W. Protein kinase A signaling as an anti-aging target. Ageing Res Rev, 2010, 9 (3): 269-72.