CAT. NO.: APE-045
| Product Details | |
|---|---|
| Alternate Name | Beta-nerve growth factor (Beta-NGF) |
| Gene Symbol | NGF |
| Gene ID | 4803 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2. |
| Molecular Weight | 25 kDA |
| Purity by SDS-PAGE | ≥95% |
| Amino Acid Sequence | Recombinant human ProNGF produced in E. coli is a non-glycosylated, non-covalently linked homodimer with each polypeptide chain containing 222 amino acids with an extra N-terminal Met and having a molecular mass of 25 kDa. The sequence of the first five N |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystine knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration. | |
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