PPP2R2A (2G9) Mouse Antibody

INQUIRY

CAT. NO.: AMA-0739

Target Information
UniProt ID	P63151

Product Details
Size	20 µL/100 µL
Reactivity	Human, Mouse, Rat, Monkey
Host	Mouse
Source/Isotype	Mouse IgG1
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp406 of rat PP2R2A/PP2A, B55-α/PR55-α protein.

Usage
Application	WB, IP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target)	52 kDa

Background
Protein phosphatase 2A subunit B isoform R2-α (PPP2R2A) is the component of regulatory subunit B of serine/threonine protein phosphatase 2A (PP2A). PPP2R2A belongs to the R2/B55/PR55 family of regulatory subunit B Evidence suggests that subunit PPP2R2A enhances TGF-β, Activin, and Nodal signaling pathways and may play an important role in cell cycle regulation PPP2R2A/PP2A, B55-α/PR55-α isoform interacts with the type I TGF-β receptors via unique WD-40 repeats that contribute to the anti-proliferative function of TGF-β receptors.

Background

Protein phosphatase 2A subunit B isoform R2-α (PPP2R2A) is the component of regulatory subunit B of serine/threonine protein phosphatase 2A (PP2A). PPP2R2A belongs to the R2/B55/PR55 family of regulatory subunit B Evidence suggests that subunit PPP2R2A enhances TGF-β, Activin, and Nodal signaling pathways and may play an important role in cell cycle regulation PPP2R2A/PP2A, B55-α/PR55-α isoform interacts with the type I TGF-β receptors via unique WD-40 repeats that contribute to the anti-proliferative function of TGF-β receptors.

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