CAT. NO.: ABS-049
| Product Details | |
|---|---|
| Alternate Name | N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo- 1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)- 3-(trifluoromethyl)benzamide; SC1 |
| CAS Number | 839707-37-8 |
| Molecular Formula | C27H25F3N8O2 |
| Molecular Weight | 550.54 |
| Appearance | White solid |
| Purity | ≥97% by HPLC |
| Solubility | DMSO (100 mM) |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C |
| PubChem CID | 12003241 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of Ras-GAP and ERK1 with Kd values of 98 and 212 nM, respectively. | |
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