Piperlongumine

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CAT. NO.: ABA-034

Product Details
Alternate Name	(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
CAS Number	20069-09-4
Molecular Formula	C₁₇H₁₉NO₅
Molecular Weight	317.34
Appearance	White to off-white solid
Purity	≥97%
Solubility	DMSO (25 mg/mL)
SMILES	COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
PubChem CID	637858
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.

Description

A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.

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