PI3 Kinase Class III Antibody
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PI3 Kinase Class III Antibody

INQUIRY

CAT. NO.: AMA-0551

Target Information
UniProt ID Q8NEB9
Product Details
Size 100 µL
Reactivity Human, Mouse, Rat
Storage Store at -20°C. Do not aliquot the antibody.
Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human PI3K class III. Antibodies are purified peptide affinity chromatography.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 100 kDa
Background
Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway.

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