CAT. NO.: AMA-0095
| Target Information | |
|---|---|
| UniProt ID | P60484 |
| Product Details | |
|---|---|
| Size | 20 μL/100 μL |
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser380 of human PTEN. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 54 kDa |
| Background | |
|---|---|
| PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K). PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis. | |
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