CAT. NO.: AMA-0057
| Target Information | |
|---|---|
| UniProt ID | O15530 |
| Product Details | |
|---|---|
| Size | 100 μL/300 μL |
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser241 of human PDK1. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:100) |
| MW (Target) | 58-68 kDa |
| Background | |
|---|---|
| Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK. Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.Several serine sites (Ser25, Ser241, Ser393/396 and Ser410) are phosphorylated on PDK1 in unstimulated human embryo kidney 293 cells, as well as IGF-1 stimulated cells. Phosphorylation on the activation loop Ser241 by autophosphorylation is necessary for PDK1 activity. | |
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