CAT. NO.: AMA-0659
| Target Information | |
|---|---|
| UniProt ID | P49023 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr118 of human paxillin protein. |
| Usage | |
|---|---|
| Application | WB, IP, IF |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50); Immunofluorescence (1:200-1:800) |
| MW (Target) | 68 kDa |
| Background | |
|---|---|
| Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin. | |
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