Products

Online Inquiry

Name*

Phone

Email*

Services or Products of Interest*

Project Description

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Phospho-p63 (Ser160/162) Antibody

INQUIRY

CAT. NO.: AMA-0318

Target Information
UniProt ID	Q9H3D4

Product Details
Size	100 µL
Reactivity	Human
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser160 of human TAp63-alpha. Antibodies are purified by protein A and peptide affinity chromatography.

Usage
Application	WB, IHC, F
Product Usage Information Dilution	Western Blotting (1:1000); Immunohistochemistry (1:150); Flow Cytometry (1:25)
MW (Target)	75 kDa

Background
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors Research investigators frequently observe amplification of the p63 gene in squamous cell carcinomas of the lung, head and neck The p63 gene contains an alternative transcription initiation site that yields a truncated ΔNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the α, β, and γ isoformsTAp63-alpha (full-length) contains multiple serine residues followed by proline (Ser-Pro motif) that are potential cdk substrates expected to be phosphorylated in mitosis. Among these are Ser160, Ser162, Ser395, and Ser455.

Background

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors Research investigators frequently observe amplification of the p63 gene in squamous cell carcinomas of the lung, head and neck The p63 gene contains an alternative transcription initiation site that yields a truncated ΔNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the α, β, and γ isoformsTAp63-alpha (full-length) contains multiple serine residues followed by proline (Ser-Pro motif) that are potential cdk substrates expected to be phosphorylated in mitosis. Among these are Ser160, Ser162, Ser395, and Ser455.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.