CAT. NO.: AMA-0592
| Target Information | |
|---|---|
| UniProt ID | Q00987 |
| Product Details | |
|---|---|
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser166 of human MDM2. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB |
| Product Usage Information Dilution | Western Blotting (1:1000) |
| MW (Target) | 90 kDa |
| Background | |
|---|---|
| MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. | |
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