CAT. NO.: AMA-0450
| Target Information | |
|---|---|
| UniProt ID | O60674 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Source/Isotype | Mouse IgG2a |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007/Tyr1008 of human Jak2 protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:100) |
| MW (Target) | 125 kDa |
| Background | |
|---|---|
| Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats Shc insulin receptor substrates and focal adhesion kinase (FAK) typically contain SH2 or other phospho-tyrosine-binding domains. | |
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